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目的探讨系统性红斑狼疮(SLE)患者外周血B淋巴细胞亚群的变化及其与体液免疫功能的关系。方法用流式细胞仪检测了27例SLE患者及16名正常对照人群的外周血B淋巴细胞亚群,并分析其与体液免疫功能的关系。结果SLE患者外周血B1淋巴细胞亚群的百分比、B1淋巴细胞亚群/B2淋巴细胞亚群的比值显著高于正常对照,并且与体内外周血中免疫球蛋白IgM的量呈正相关。除此之外,抗dsDNA抗体阳性组的SLE患者外周血B1淋巴细胞亚群(%)及B1/B2比值均高于阴性组。结论SLE患者外周血B1淋巴细胞亚群存在异常,可能与SLE患者体内的体液免疫异常有关,并在SLE的发病中具有重要作用。
Objective To investigate the changes of peripheral blood B lymphocyte subsets in patients with systemic lupus erythematosus (SLE) and its relationship with humoral immune function. Methods Flow cytometry was used to detect the B lymphocyte subsets in peripheral blood of 27 SLE patients and 16 normal control subjects. The relationship between them and humoral immune function was analyzed. Results The percentage of B1 lymphocyte subsets, B1 lymphocyte subsets / B2 lymphocyte subsets in peripheral blood of SLE patients was significantly higher than that of normal controls and positively correlated with the amount of immunoglobulin IgM in peripheral blood. In addition, the percentage of B1 lymphocyte subsets (%) and B1 / B2 in SLE patients with anti-dsDNA antibody-positive group were higher than those in negative group. Conclusion Abnormalities of B1 lymphocyte subsets in peripheral blood of patients with SLE may be related to humoral immune abnormalities in SLE patients and play an important role in the pathogenesis of SLE.