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目的探讨金双歧联合葡萄糖酸锌治疗小儿厌食症的临床效果。方法将146例厌食症患儿随机分为观察组74例和对照组72例;对照组给予金双歧片口服治疗,观察组在对照组的基础上加服葡萄糖酸锌片;用药4周后观察两组患儿的临床疗效和用药安全性,ELISA法检测治疗前后两组患儿血清瘦素(Leptin)、胃促生长素(Ghrelin)的水平变化。结果观察组的临床总有效率为91.89%,与对照组的69.44%比较差异有统计学意义(P<0.05);两组患儿治疗后血清Leptin水平增加、Ghrelin水平降低,与治疗前比较差异均有统计学意义(P<0.05),且观察组优于对照组差异有统计学意义(P<0.05);两组不良反应比较差异无统计学意义(P>0.05)。结论金双歧联合葡萄糖酸锌治疗小儿厌食症安全有效,其促食欲的作用可能与Leptin和Ghrelin的分泌调节有关。
Objective To investigate the clinical effect of Jinshuangqi combined with zinc gluconate on children with anorexia. Methods 146 cases of children with anorexia were randomly divided into observation group (74 cases) and control group (72 cases). The control group was treated with Jinshuifu tablets orally. The observation group was given zinc gluconate tablets on the basis of the control group. After 4 weeks of treatment, The clinical efficacy and medication safety of the children were evaluated. The levels of serum Leptin and Ghrelin in both groups were detected by ELISA before and after treatment. Results The total effective rate of the observation group was 91.89%, which was significantly different from that of the control group (69.44%) (P <0.05). The levels of Leptin and Ghrelin in the two groups were significantly lower than those before treatment (P <0.05), and the difference between the observation group and the control group was statistically significant (P <0.05). There was no significant difference in adverse reactions between the two groups (P> 0.05). Conclusion Jinshuangqi combined with zinc gluconate in the treatment of children with anorexia is safe and effective, and its appetite-promoting effect may be related to the secretion regulation of Leptin and Ghrelin.