论文部分内容阅读
作者报道不同人群免疫水平,普通人群与免疫人群不同暴露率,对优势比影响的模拟分析和一次流行性出血热病例对照研究中易感人群对照和普通人群对照的对比分析结果.发现当易感人群对研究因素的暴露率与普通人群接近时,两种对照的结果也很接近.当上述两种人群暴露率有明显差别时,则两种对照所得优势比也有明显差别,但分别与其相应目标人群的相对危险度接近.据此作者认为,传染病病例对照研究中对照组是否需要血清学筛检取决于:①筛检效益;②研究的目的及暴露与易感性是否有联系.如果两者无明显联系,或者欲得普通人群优势比,以普通人群对照为宜.若欲估计易感人群的优势比,则应选择易感人群对照.
The authors report on different groups of immunization levels, the general population and immune population exposure rate differences, the simulation analysis of the odds ratio and a case-control study of epidemic Epidemic Haemorrhagic Contraction in susceptible population control and the general population control comparative analysis results found that when susceptible When the exposure rate of the research population to the research population is close to that of the general population, the results of the two kinds of control are also very close.When there is a significant difference in the exposure rates between the two groups, the odds ratios of the two control groups are also significantly different from those of the corresponding groups The relative risk of the population is close, according to which the author believes that the need for serological screening of control groups in case-control studies of infectious diseases depends on: screening effectiveness; the purpose of the study and whether there is a link between exposure and susceptibility; No obvious relationship, or want the general population odds ratio to the general population control is appropriate.If you want to estimate the susceptibility of the population than the odds ratio, you should choose the susceptible population control.