论文部分内容阅读
环磷腺苷(cAMP)控制心脏 Ca~(++)慢通道的作用常被忽视,本文复习和总结心肌慢通道的某些重要特性,特别是 cAMP 对它的调节。此外,简单讨论慢动作电位(APs)、钙拮抗剂的作用机制以及慢动作电位在心律失常发生中可能具有的作用.在兴奋-收缩耦联过程中,心脏收缩力是由动作电位期间跨细胞膜流入的 Ca~(++)所控
The role of cyclic adenosine monophosphate (cAMP) in the control of the slow Ca ~ (++) channel in the heart is often overlooked. This review and summary of some of the important properties of the slow pathway in the myocardium, in particular its regulation by cAMP. In addition, a brief discussion of the slow-acting potentials (APs), the mechanism of action of calcium antagonists, and the possible role of slow-acting potentials in the development of cardiac arrhythmias is shown in Figure 1. In the excitatory-contractile coupling process, cardiac contractility is caused by the action potential across cell membranes Influx of Ca ~ (++) controlled