克山病病区人群和用病区粮饲养的动物血中谷胱甘肽过氧化物酶活力的研究

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1.比较了用病区和非病区玉米、大米饲料饲养的大白鼠的全血中GSH-px活力,并与吃常备饲科的大白鼠血GSH-px活力进行对比。结果是:常备饲料组的酶活力大于非病区??粮组和病区粮组的,非病区粮组的酶活力大于病区粮组的。同时测定体外用维生素C氧化血红蛋白生成的高铁血红蛋白,胆绿蛋白和Heinz小体的百分数,所得结果是:常备饲料组小于非病区粮组和病区粮组,非病区粮组小于病区粮组。2.给喂以病区玉米饲料三个月造成乏硒的大白鼠补充硒(Na_2SeO_3)50天后,血硒和红细胞GSH-px活力均上升到接近喂以常备饲料的大白鼠的水平。3.测定了非病区儿童和成人及病区的克山病患儿和非克山病儿童和成人的全血GSH—px活力,结果是:职工户儿童大于农业户儿童,非病区儿童大于病区儿童。病区的非克山病儿童的酶活力与克山病患儿的无明显差别。4.克山病地区的儿童按规定服用亚硒酸钠后,GSH-px活力明显上升,达到70单位左右。5.人群的GSH-px活力与血硒和发硒有非常显著的相关性。 1.Compared GSH-px activity in whole blood of rats fed on ward and non-wedged maize and rice, and compared GSH-px activity of GSH-px in rats fed on standing diet. As a result, the enzyme activity of the normal feed group was higher than that of the non-diseased area. The enzyme activity of the non-diseased group was higher than that of the ward. Meanwhile, the percentages of methemoglobin, ghrelin and Heinz bodies produced by vitamin C oxidized hemoglobin in vitro were also determined. The results were as follows: the group of fed-batch was smaller than the group of non-ward and the group of ward, and the group of non- Food group. After 50 days of supplementation of selenium (Na_2SeO_3) in selenium-deficient rats fed with ward corn feed for three months, the activity of GSH-px in blood selenium and erythrocytes increased to nearly the level in rats fed with normal diet. 3. Determination of GSH-px activity in whole blood of children with Keshan disease and non-Keshan disease in both non-ward children and adults and ward, the results are: workers and families of children than children of agricultural households, non-ward children More than ward children. Wicked mountain ward children’s enzyme activity and Keshan disease in children no significant difference. 4. Keshan disease area children taking sodium selenite as required, GSH-px activity increased significantly, reaching about 70 units. 5. The GSH-px activity of the crowd has a very significant correlation with selenium and selenium.
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