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探讨食管鳞癌患者ERCC1、TYMS、TUBB3的表达特征,以及其与化疗效果的相关性。选择2013年8月~2014年8月我科收治的食管癌患者78例,于术后采用液相芯片技术对食管癌组织ERCC1、TYMS、TUBB3基因m RNA表达水平进行检测,所有患者均按指南所载方案进行化疗,并统计患者1年复发情况。ERCC1、TYMS、TUBB3表达阳性表达率分别为48.7%、70.5%、61.5%,ERCC1表达阳性率与年龄,TNM分期、组织分化程度等因素有关,TUBB3表达阳性率与性别有关,发病部位为食管上段的患者TYMS表达阳性率更高,差异均具有统计学差异。TYMS与TUBB3呈现出弱相关性,ERCC1表达与TYMS、TUBB3与均无相关性。2或3项基因阳性患者1年复发率显著高于0或1项基因阳性患者,分别为29.8%、9.7%。食管鳞癌患者ERCC1、TYMS、TUBB3表达具有特定的临床特征,高表达与复发率增加有关。
To investigate the expression characteristics of ERCC1, TYMS and TUBB3 in patients with esophageal squamous cell carcinoma and its correlation with chemotherapy efficacy. From August 2013 to August 2014, 78 patients with esophageal cancer who were treated in our department were enrolled in this study. The mRNA expression of ERCC1, TYMS and TUBB3 in esophageal cancer tissues was detected by liquid-phase microarray after operation. All patients were guided by the guidelines The program contained chemotherapy, and statistics of patients 1 year recurrence. The positive expression rates of ERCC1, TYMS and TUBB3 were 48.7%, 70.5% and 61.5% respectively. The positive rate of ERCC1 expression was related to the age, TNM stage and histological differentiation. The positive rate of TUBB3 expression was related to sex, Of patients had higher positive rate of TYMS expression, the differences were statistically significant. TYMS and TUBB3 showed a weak correlation, ERCC1 expression and TYMS, TUBB3 and no correlation. The 1-year recurrence rate of 2 or 3 gene positive patients was significantly higher than that of 0 or 1 gene positive patients, accounting for 29.8% and 9.7% respectively. The expression of ERCC1, TYMS and TUBB3 in patients with esophageal squamous cell carcinoma has certain clinical features, which is related to the high recurrence rate.