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本论文以水杨醛为主要原料，经发烟硝酸硝化合成５－硝基水杨醛，再分别与对氟苯胺、邻甲苯胺、邻氯苯胺及均三嗪的衍生物作用，合成了四种席夫碱，其中与对氟苯胺、邻甲苯胺、均三嗪的衍生物作用合成而得的席夫碱未见报道。对所合成的四种席夫碱进行生物活性测试，结果表明，该四种席夫碱对供试菌种（大肠杆菌、假丝酵母菌、毛霉菌、鼠伤寒沙门氏菌）都有一定的抑制作用，对细菌的抑制作用强于对霉菌的抑制作用，且浓度愈高抑菌作用愈强。对氟苯胺席夫碱抑菌效果最为特出，是一种潜在的抑菌剂，可进一步深入研究。
In this paper, salicylaldehyde as the main raw material, the nitration of fuming nitric acid synthesis of 5-nitro-salicylaldehyde, respectively, and p-fluoroaniline, o-toluidine, o-chloroaniline and triazine derivatives, the synthesis of tetra Schiff base, which with the p-fluoroaniline, o-toluidine, are triazine derivative derived from the role of Schiff’s base has not been reported. The biological activities of the four Schiff bases were tested and the results showed that the four Schiff bases have certain inhibitory effects on the tested strains (E. coli, Candida, Mucor, Salmonella typhimurium) , The inhibition of bacteria stronger than the inhibitory effect on mold, and the higher the concentration of antibacterial effect stronger. Fluoroaniline Schiff base antibacterial effect of the most peculiar, is a potential bacteriostatic agent, can be further in-depth study.