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[目的]比较含左旋氧氟沙星的10d序贯疗法与传统三联疗法对Hp阳性的消化性溃疡患者的疗效。[方法]将89例Hp阳性的患者随机分为两组,观察组45例前5d给予奥关拉唑40mg+阿莫西林l.09,后5d给予奥美拉唑40mg+左氧氟沙星0.49+克拉霉素0.59,对照组44例给予奥关拉唑40mg+克拉霉素0.59+阿莫西林1.09,完成治疗后28d和6个月复查胃镜及Hp检测。[结果]观察组Hp清除率为93.0%,溃疡愈合率为81.4%,远高于对照组的79.6%和61.2%(P﹤0.05);观察组溃疡复发率为12.5%,低于对照组的33.3%(P﹤0.05)。[结论]含左旋氧氟沙星的10d序贯疗法对Hp阳性的消化性溃疡的疗效优于传统三联疗法,近期复发率较低。
[Objective] To compare the efficacy of 10-day sequential therapy with levofloxacin and traditional triple therapy in patients with Hp-positive peptic ulcer. [Method] Eighty-nine patients with positive Hp were randomly divided into two groups. In the observation group, 45 patients were given omeprazole 40mg and amoxicillin l.09 before the first 5 days, and omeprazole 40mg and levofloxacin 0.49 and clarithromycin 0.59 , 44 cases in the control group were given omeprazole 40mg + clarithromycin 0.59+ amoxicillin 1.09, gastroscopy and Hp test were performed at 28 and 6 months after the completion of treatment. [Results] The Hp clearance rate was 93.0% and the ulcer healing rate was 81.4% in the observation group, which was much higher than 79.6% and 61.2% in the control group (P <0.05). The recurrence rate of ulcer in the observation group was 12.5% 33.3% (P <0.05). [Conclusion] The 10-day sequential therapy with levofloxacin is superior to the traditional triple therapy in the treatment of Hp-positive peptic ulcer. The recent recurrence rate is low.