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在美国有1400万人患有变应性鼻炎。为了进一步弄清变应性鼻炎的病理生理,以改进其治疗,作者们进行了变应原鼻粘膜激发试验,以测定在变应性鼻炎发病过程中鼻分泌物中介质水平与过敏症状(喷嚏)出现的情况。实验观察发现变应性个体在激发试验时鼻分泌物中组胺、甲苯磺酰精氨酸甲酯(TAME)酯酶,前列腺素D_2(PGD_2)、激肽、白细胞三烯C_2的水平均增高,同时出现喷嚏,以后介质水平降至正常。症状亦消失。而非变应性个体激发后无喷嚏出现,但鼻分泌物中介质水平也增高。两组事先应用哌吡庚啶(azatadine),
Almost 14 million people in the United States have allergic rhinitis. In order to further understand the pathophysiology of allergic rhinitis to improve its treatment, the authors performed an allergic rhinosinusitis test to determine the level of media and allergic symptoms in nasal secretions during the onset of allergic rhinitis (sneeze ) Appears. Experimental observation found that the levels of histamine, TAME esterase, prostaglandin D_2 (PGD_2), kinin and leukotriene C_2 in nasal secretions were significantly increased in allergic individuals during stimulation test , While sneezing, after the medium level to normal. Symptoms disappear. Non-allergic individuals without provoking sneezing, but nasal secretions medium levels are also increased. Two groups of prior application of piperdine (azatadine),