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对203例结核病患者用含吡嗪酰胺(PZA)方案治疗产生肝脏毒性进行分析,发生率为16.7％,较国内外报告的1～5％为高。5种含PZA方案肝毒性反应的发生率无差异(P>0.05),91％肝毒性发生在开始治疗两个月内,绝大多数预后良好。肝功能的GPT100单位以下者多在4周内恢复,100单位及以上者大多需8周以上恢复正常。如伴有黄疸个别可出现严重肝功能损害。提示含PZA方案一般较安全,但应严格掌握含PZA方案的适应症;用药早期要注意作好肝功能监测。
203 cases of tuberculosis patients with pyrazinamide (PZA) regimen of liver toxicity were analyzed, the incidence was 16.7%, higher than the domestic and international reports of 1 to 5%. There was no difference in the incidence of hepatotoxicity among the five PZA-containing regimens (P> 0.05). 91% of hepatotoxicity occurred within two months after the initiation of treatment, with the vast majority of patients with good prognosis. Most of GPT100 units with liver function recovered within 4 weeks, and most of those with 100 units or more needed to return to normal within 8 weeks. If accompanied by jaundice individual serious liver damage may occur. Tips PZA containing programs generally safer, but should be strictly controlled with PZA program indications; medication should pay attention to early liver function monitoring.