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近年来,天然物中有生理活性成分的全合成是有机化学重要发展方向之一。这些复杂化合物大都带有许多手征性中心,对合成带来较大的困难。从适当的有旋光活性的天然物出发,作为中间体进行这类化合物的全合成,是最近所发展的解决这一问题的重要方法,可以大大简化合成步骤,克服立体化学上的困难。本文介绍了从D-葡萄糖开始,通过立体控制地引入适当功能基,得到了两个歧链糖Ⅰ及Ⅱ,可以作为
In recent years, the total synthesis of physiologically active ingredients in natural products is one of the important development directions of organic chemistry. Most of these complex compounds with many chiral centers, the synthesis of more difficult. Starting from a suitable optically active natural product, the complete synthesis of such compounds as intermediates is an important method recently developed to solve this problem, greatly simplifying the synthesis steps and overcoming the stereochemical difficulties. This article describes the introduction of D-glucose and the introduction of appropriate functional groups by stereospecific control to give two branched-chain sugars I and II, which can be used as