论文部分内容阅读
获得性血友病是由于产生中和血浆第Ⅷ凝血因子的抗体(抗-Ⅷ)而引起的。这种罕见病的临床表现与先天性血友病相似,典型病例为老年和女性。虽然许多患者没有并发疾病,但已认识到与那些有“自身免疫”或过敏因素的疾病有关,包括类风湿关节炎等胶原-血管病、癌症、天疱疮、溃疡性结肠炎和哮喘等。较年轻病人最常见于正常妊娠后。也可作为药物治疗的副作用而表现出来,特别是青霉素。获得性血友病的诊断依赖于临床上识别没有此种病史的病人出现出血倾向。与先天性血友病一样,全
Acquired hemophilia is caused by the production of an antibody that neutralizes plasma VIII, a factor VIII (anti-VIII). The clinical manifestations of this rare disease are similar to those of congenital hemophilia, with typical cases of elderly and females. Although many patients have no concurrent disease, they have been recognized to be associated with diseases that have “autoimmune” or allergies, including collagen-vascular disease such as rheumatoid arthritis, cancer, pemphigus, ulcerative colitis and asthma. The younger patients are most common after normal pregnancy. It can also be shown as a side effect of medical treatment, especially penicillin. The diagnosis of acquired hemophilia depends on the clinical identification of patients who have no such history of bleeding tendency. Like congenital hemophilia, all