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目的:研究蓝萼甲素的抗血栓作用。方法:考察蓝萼甲素对SD大鼠的血小板聚集性、血瘀模型大鼠血浆中TXB2、6-Keto-PGF1α以及NO和ET含量的影响,通过大鼠动-静脉旁路血栓形成实验、ADP-肾上腺素诱发小鼠体内血栓形成实验、急性血瘀模型大鼠血液流变学实验、大鼠离体动脉条的舒张实验,研究蓝萼甲素的抗血栓作用,并初步探讨其机制。结果 :蓝萼甲素浓度依赖性降低ADP以及凝血酶所诱导的血小板聚集;降低血瘀模型大鼠血浆中TXB2含量,显著升高血浆中6-KetoPGF1α含量,升高血浆中NO的含量,降低血浆中ET含量;蓝萼甲素对大鼠动-静脉旁路血栓形成有抑制作用,对ADP-肾上腺素混合溶液诱导的小鼠血栓性偏瘫形成有保护作用;显著降低急性血瘀模型大鼠的全血及血浆黏度,蓝萼甲素依赖内皮细胞发挥舒张血管作用,而且与NO合成通路密切相关。结论:蓝萼甲素通过抑制血小板聚集,抑制血栓形成,降低全血及血浆黏度,舒张血管,从而发挥抗血栓作用。
Objective: To study the antithrombotic effect of blue caluridine. Methods: To investigate the effect of blue calvariae on platelet aggregation in rats, the content of TXB2, 6-Keto-PGF1α and NO and ET in plasma of blood stasis model rats. By the experiment of rat veno-venous bypass thrombosis, ADP-adrenergic-induced thrombosis in mice, hemorheology in rats with acute blood stasis, and relaxation in isolated arterial strips of rats were performed to study the antithrombotic effect of hydrocortisone A and its mechanism. Results: CVEF decreased the levels of platelet aggregation induced by ADP and thrombin in a concentration-dependent manner, decreased the content of TXB2 in plasma, increased the content of 6-KetoPGF1α in plasma and the content of NO in plasma Plasma ET content; blue calurin alpha on rat venous bypass thrombosis was inhibited ADP-adrenaline mixed solution induced thrombosis in mice with a protective effect; significantly reduced acute blood stasis model rats Of whole blood and plasma viscosity, blue calurin-dependent endothelial cells play a role in relaxation of blood vessels, but also with the NO synthesis pathway is closely related. Conclusion: Clarithromycin can exert antithrombotic effect by inhibiting platelet aggregation, inhibiting thrombosis, lowering whole blood and plasma viscosity and relaxing blood vessels.