论文部分内容阅读
New photoaffinity ligand candidates were synthesized based on 5-t-butyl-2-(4-(substituted-ethynyl)phenyl)-1, 3-dithiane for the noncompetitive blocker site on the gamma-aminobutyric acid -gated chloride channel. Their half-maximal inhibition concentrations ranged from 4 to 32 nmol/L as measured by 4’-ethynyl-4-n-[2,3-3H2]-propylbicycloorthobenzoate (3H EBOB) assay.
New photoaffinity ligand candidates were synthesized based on 5-t-butyl-2- (4- (substituted-ethynyl) phenyl) -1, 3-dithiane for the noncompetitive blocker site on the gamma-aminobutyric acid -gated chloride channel. -maximal inhibition concentrations ranged from 4 to 32 nmol / L as measured by 4’-ethynyl-4-n- [2,3-3H2] -propylbicycloorthobenzoate (3H EBOB) assay.