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目的:观察诱导型一氧化氮合酶(iNOS)基因Ser608Leu位点基因多态性与2型糖尿病的相关性。方法:采用测序法测定261例2型糖尿病患者和128例正常对照者iNOS基因Ser608Leu位点基因多态性。结果:两组间iNOS基因Ser608Leu位点基因型及等位基因频率构成存在差异。结论:iNOS基因Ser608Leu位点多态性与2型糖尿病有关。
Objective: To investigate the relationship between the gene polymorphism of Ser608Leu in inducible nitric oxide synthase (iNOS) gene and type 2 diabetes mellitus (T2DM). Methods: Sequencing was used to determine the Ser608Leu locus polymorphism of iNOS gene in 261 type 2 diabetic patients and 128 normal controls. Results: The frequencies of genotypes and alleles of Ser608Leu in iNOS gene were different between the two groups. Conclusion: Ser608Leu polymorphism of iNOS gene is associated with type 2 diabetes mellitus.