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目的:检测冠心病(coronary heart disease,CHD)患者血清中S100A12含量,探讨其血清S100A12升高对冠心病风险的评估价值。方法:CHD组为明确诊断的冠心病患者128例,对照组为冠状动脉CTA或冠脉造影正常的患者61例,观察血清S100A12水平在两组间的变化,观察与冠脉病变的严重程度是否存在相关性。对包括血清S100A12高水平在内等危险因素进行Logistic回归。结果:冠心病患者组血清S100A12水平[(43.57±10.30)ng/ml]显著高于非冠心病患者组[(25.63±7.42)ng/ml],差异有统计学意义(P<0.001),且与冠脉狭窄程度Gensini评分呈正相关(r=0.391,P<0.001);以冠心病发病为因变量,以年龄、男性、体质指数超标、高血压、糖尿病、血脂异常、血清S100A12高水平为自变量,结果发现,在排除了其他危险因素之后,血清S100A12高水平(OR=2.67,P<0.001)为冠心病相关的独立危险因素。结论:血清中S100A12水平可能是潜在的预测冠心病风险的生物学指标。
Objective: To investigate the serum levels of S100A12 in patients with coronary heart disease (CHD) and evaluate the value of serum S100A12 in the diagnosis of coronary heart disease. Methods: A total of 128 CHD patients with definite diagnosis of CHD were enrolled. The control group consisted of 61 patients with coronary artery CTA or normal coronary angiography. The changes of serum S100A12 level were observed between the two groups. Observe whether the severity of coronary artery disease There is a correlation. Logistic regression was performed for other risk factors, including high levels of serum S100A12. Results: The level of serum S100A12 in patients with coronary heart disease was significantly higher than that in non-patients with coronary heart disease [(43.57 ± 10.30) ng / ml [(25.63 ± 7.42) ng / ml, P <0.001) (R = 0.391, P <0.001). According to the incidence of coronary heart disease as the dependent variable, the age, male, excess body mass index, hypertension, diabetes, dyslipidemia and high level of serum S100A12 The results showed that the high level of serum S100A12 (OR = 2.67, P <0.001) was an independent risk factor for CHD after excluding other risk factors. Conclusion: Serum levels of S100A12 may be potential biomarkers for predicting the risk of coronary heart disease.