【摘 要】
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Renin-angiotensin-aldosterone system (RAAS) blockade is often the first-line medication for treating pediatric and adult patients with hypertension,especially those with pre-existing chronic kidney disease (CKD) [1,2].However,the rise in serum creatinine
【机 构】
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Division of Nephrology,Department of Pediatrics,Rush University Medical Center,445 E.North Water Str
论文部分内容阅读
Renin-angiotensin-aldosterone system (RAAS) blockade is often the first-line medication for treating pediatric and adult patients with hypertension,especially those with pre-existing chronic kidney disease (CKD) [1,2].However,the rise in serum creatinine and potassium concentrations following RAAS blocked may pose therapeutic challenges whether it is safe to treat hypertensive patients with CKD,by inhibiting [3].Thus,many clinicians neglect to use angi-otensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blockade (ARB) especially in patients with CKD because of fear in either reduction of glomerular filtration rate (GFR) or elevation in serum creatinine and potassium concentrations.
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