论文部分内容阅读
目的 探讨新疆维吾尔族、汉族人群中谷胱甘肽S 转移酶 (glutathioneS transferase,GST)M 1、T1纯合缺失基因型 (- / - )与子宫内膜异位症 (内异症 )发病的关系。方法 采用PCR技术 ,分别对维吾尔族 10 7例正常妇女 (维族对照组 )及 4 1例内异症患者 (维族内异症组 )、汉族 10 5例正常妇女 (汉族对照组 )及 80例内异症患者 (汉族内异症组 )基因组DNA进行GSTM1、GSTT1基因分型。结果 维族内异症组GSTM 1(- / - )、GSTT1(- / - )基因型及两种基因同时缺失的基因型频率分别为 5 1 2 %、36 6 %、2 4 4 % ,维族对照组为 5 3 2 %、2 9 9%、13 1% ,两组比较 ,差异无显著性(P >0 0 5 )。汉族内异症组与汉族对照组GSTM1(- / - )基因型频率分别为 5 6 8%、5 1 8% ,两组比较 ,差异也无显著性 (P >0 0 5 ) ;而GSTT1(- / - )基因型频率分别为 73 7%、4 4 3% ,两组比较 ,差异有显著性 (P <0 0 5 ) ;汉族内异症组、汉族对照组两种基因同时缺失的基因型频率为 4 2 5 %、2 2 8% ,两组比较 ,差异有显著性 (P <0 0 5 )。维族与汉族比较 ,对照组GSTM 1(- / - )、GSTT1(- /- )基因型及两种基因同时缺失的基因型比较 ,差异无显著性 (P >0 0 5 ) ;内异症组GSTM 1(- / - )、两种基因同时缺失的基因型比较 ,差异也无?
Objective To investigate the relationship between the genotype of glutathione S transferase (GST) M1, T1 homozygous deletion (- / -) and endometriosis (endometriosis) in Uygur and Han ethnic groups in Xinjiang Uygur Autonomous Region. . Methods A total of 10 Uygur women (Uygur control group) and 41 endometriosis patients (Uygur endometriosis group), 105 normal Han women (Han control group) and 80 normal controls Genomic DNA of patients with abnormalities (Han endometriosis group) were genotyped by GSTM1 and GSTT1. Results The frequency of GSTM1 (- / -), GSTT1 (- / -) genotypes and the simultaneous deletion of the two genes in Uygur endometriosis group were 51.2%, 36.6% and 24.4% The group was 53.2%, 29.9% and 13.1%, respectively. There was no significant difference between the two groups (P> 0.05). The frequencies of GSTM1 (- / -) genotype in Han patients and Han controls were 56.8% and 51.8%, respectively. There was no significant difference between the two groups (P> 0.05) - / -) genotype frequencies were 73.7% and 44.3%, respectively, with significant difference between the two groups (P <0.05). The frequencies of both genotypes of Han and Han controls were also decreased Type frequency was 42.5%, 22.8%, the difference between the two groups was significant (P <0 05). There was no significant difference in the genotypes of GSTM1 (- / -), GSTT1 (- / -) and two genes in the control group between Uygur and Han nationality (P> 0.05) GSTM 1 (- / -), two genes simultaneously deleted genotypes, the difference is not?