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目的探讨妇科门诊患者宫颈HPV感染状况及基因型分布。方法采用核酸分子快速导流杂交分型技术,对在本院妇科就诊的3 652名女性患者宫颈拭子进行HPV分型检测。结果 21种HPV亚型均被检出,3 652例门诊妇女中HPV阳性率为36.7%(1 342/3 652),检出率在5%以上的亚型有5种,依次为HPV 16(9.7%,354/3 652)、HPV52(7.2%,262/3 652)、HPV 11(6.9%,252/3 652)、HPV 58(6.8%,248/3 652)和HPV 6(5.6%,203/3 652)。结论妇科门诊患者HPV感染率较高,应开展HPV DNA常规检测,以预防宫颈癌的发生。
Objective To investigate the cervical HPV infection status and genotype distribution in gynecology clinic. Methods Using rapid flow-through hybridization of nucleic acid molecules, 3 652 female patients with cervical gynecological examination in our hospital were tested for HPV typing. Results Twenty-one HPV subtypes were detected. The positive rate of HPV was 36.7% (1 342/3 652) in 3 652 outpatients and 5 subtypes with 5% detection rate were HPV 16 ( HPV58 (6.8%, 248/3652) and HPV6 (5.6%, respectively) were significantly higher in HPV52 (7.2%, 262/3652), HPV11 203/3 652). Conclusions The prevalence of HPV infection in gynecology outpatients is high. HPV DNA should be routinely tested to prevent the occurrence of cervical cancer.