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对38例先天性心脏病患儿体外循环心脏手术前后的甲襞微循环和血液流变性进行监测。结果发现:患儿术后早期甲襞微循环出现管袢数目减少、轮廓模糊,微血流呈粒流、粒缓流,RBC聚集;患儿的血液粘度及血浆肢体渗透压显著降低,而红细胞刚性指数显著升高(P均<0.01)。上述结果提示:体外循环心脏手术期间的低温、血液稀释、体外循环机械作用及预充液成分等因素是影响围术期患儿甲襞微循环和血液流变性的主要因素。为改善患儿手术的预后,术后应加强对甲襞微循环和血液流变性指标的监测并及时调节和改善其异常的微循环和血液流变性状态。
Thirty-eight children with congenital heart disease underwent cardiopulmonary bypass during and after cardiopulmonary bypass were monitored for microcirculation and hemorrheology. The results showed that: the early postoperative nodules microcirculation appear reduced the number of tube loop, fuzzy outline, micro-flow was granular flow, granular slow flow, RBC aggregation; children’s blood viscosity and plasma body osmotic pressure decreased significantly, while the red blood cells Rigidity index increased significantly (all P <0.01). These results suggest that factors such as hypothermia, hemodilution, cardiopulmonary bypass and prefill components during cardiopulmonary bypass are major factors that influence peri-arrhythmia in children with formazan microcirculation and hemorrheology. To improve the prognosis of children with surgery, postoperative should strengthen the monitoring of nailfold microcirculation and hemorrheological indicators and timely adjustment and improvement of its abnormal microcirculation and hemorrheological status.