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严重感染引起高分解代谢,其中骨骼肌的蛋白质分解尤其重要。感染引起骨骼肌的蛋白质分解代谢增加,合成代谢受抑,净蛋白分解率(NPC)增加,蛋白丢失,肌肉衰竭。在感染不同时期,不同类型的肌肉及肌肉的不同部位其改变均不同。这些代谢改变是机体神经、内分泌、细胞素及细胞内机制一系列介质共同作用的结果。其中分解激素环境及细胞素(白介素-1 IL-1、肿瘤坏死因子TNF)的作用得到重视。目前的研究致力于寻找血浆中的循环致蛋白分解因子。
Serious infections cause high catabolism, of which skeletal muscle protein breakdown is particularly important. Infection causes skeletal muscle protein catabolism increased, anabolic inhibition, increased net protein breakdown (NPC), protein loss, muscle failure. In different stages of infection, different types of muscles and muscles in different parts of their changes are different. These metabolic changes are the result of a series of mediators of the body’s nerves, endocrine, cytokines and intracellular mechanisms. Among them, the role of the decomposition of hormone environment and cytokines (interleukin-1 IL-1, tumor necrosis factor TNF) has been taken seriously. Current research is focused on finding circulating circulating proteolytic factors in the plasma.