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我们用荷Ｌｅｗｉｓ肺癌的ＮＩＨ小鼠，以平均直径倍增时间为终点，进行热耐受动力学研究。将带瘤腿浸入４３±０．１℃的水浴中进行局部加温。小鼠以腹腔注射６０ｍｇ／ｋｇ戊巴比妥钠麻醉。在４３℃加温２５ｍｉｎ后，间隔０，８，１６，２４，４８，７２，９６，１２０，１４４，１６８，１９２，２１６和２４０ｈ再给第２次加温。结果表明，４３℃加温２５ｍｉｎ后，肿瘤迅速产生热耐受性，在２４ｈ达到最大值，然后逐渐减弱，而在９６ｈ后减弱很慢。热耐受性的存在，减弱第二次加温的疗效。
We used NIH mice bearing Lewis lung cancer to study the thermal tolerance kinetics using the mean diameter doubling time as the endpoint. The tumor-bearing leg was immersed in a water bath at 43±0.1°C for local warming. Mice were anesthetized with an intraperitoneal injection of 60 mg/kg sodium pentobarbital. After warming at 43°C for 25 min, the second warming was performed at intervals of 0, 8, 16, 24, 48, 72, 96, 120, 144, 168, 192, 216 and 240 h. The results showed that after heating at 43 °C for 25 min, the tumor quickly developed thermal tolerance, reached a maximum at 24 h, then gradually decreased, and attenuated slowly after 96 h. The presence of heat tolerance weakened the efficacy of the second warming.