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目的 探讨非肥胖正常人与肥胖患者及糖尿病患者血浆Leptin(瘦素 )的关系。方法 采用放射免疫分析法测定了 2 1例非肥胖正常人 ,2 4例肥胖患者及 2 0例肥胖伴糖尿病患者血浆Leptin水平。 结果 肥胖患者血浆Leptin水平 (1 0 9.1± 1 6 .4pg/ml)及肥胖伴糖尿病患者血浆Leptin水平 (81 .0± 1 7.5pg/ml)显著低于非肥胖正常人 (1 94.3± 1 7.7pg/ml)。 结论 非肥胖正常人及肥胖患者血浆Leptin水平与体重指数、血糖、胆固醇及甘油三脂呈显著负相关 ,表明人的Leptin在调节体重及内分泌代谢方面起一定的作用。
Objective To investigate the relationship between leptin (leptin) and non-obesity normal subjects and obese patients and diabetic patients. Methods The level of plasma leptin in 21 non-obese normal subjects, 24 obese patients and 20 obese patients with diabetes mellitus was determined by radioimmunoassay. Results The level of Leptin in obese patients (110 ± 16.7 pg / ml) and obese diabetic patients (81.0 ± 7.5 pg / ml) were significantly lower than those in non-obese subjects (1 94.3 ± 1 7.7 pg / ml). Conclusion There is a significant negative correlation between plasma leptin level and body mass index, blood glucose, cholesterol and triglyceride in non-obese normal subjects and obese subjects, indicating that human Leptin plays a role in the regulation of body weight and endocrine metabolism.