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目的观察固定剂量的培哚普利和氨氯地平联用治疗原发性高血压的有效性和耐受性。方法未经治疗的Ⅱ级高血压(BP≥160/100mm Hg)患者、单一药物或其他合并用药未能控制的高血压(BP≥140/90mm Hg)患者进行观察。患者每天服用固定剂量的培哚普利(4mg)和氨氯地平(5mg)共60d。给药前、给药15、30d以及60d分别测定患者血压。服药期间每周进行常规检查、随访不良事件及依从性。结果试验共纳入112名患者,其中有106名完成60d的治疗。治疗60d后所有患者平均收缩压和舒张压相对于治疗前显著降低(-41.9±8.5/-22.8±5.6)mm Hg,分别降低25.8%和22.9%。所有患者67.8%经治疗后血压达标。对亚组进行分析:未经治疗的高血压患者、单一药物没有控制的高血压患者以及其他合并用药没能控制血压的患者经治疗后血压达标62.8%、62.3%和58.8%。固定剂量的培哚普利和氨氯地平联用安全、耐受。结论固定剂量的培哚普利和氨氯地平联用为治疗原发性高血压安全、有效的治疗方法,并且临床依从性好。
Objective To observe the efficacy and tolerability of fixed doses of perindopril combined with amlodipine in the treatment of essential hypertension. Methods Patients with untreated grade II hypertension (BP ≥ 160/100 mm Hg), single-agent or other uncontrolled hypertension (BP ≥ 140/90 mm Hg) were observed. Patients took a fixed dose of perindopril (4 mg) and amlodipine (5 mg) daily for 60 days. Before administration, 15, 30 and 60 days after administration, blood pressure was measured. During the medication routine weekly checks, follow-up adverse events and compliance. Results A total of 112 patients were included in the trial, of whom 106 completed 60 days of treatment. After 60 days of treatment, the average systolic and diastolic blood pressure of all patients decreased significantly (-41.9 ± 8.5 / -22.8 ± 5.6) mm Hg compared with that before treatment, with a decrease of 25.8% and 22.9% respectively. 67.8% of all patients achieved blood pressure after treatment. Subgroup analysis: untreated hypertensive patients, single-drug uncontrolled hypertensive patients, and other combined medication can not control blood pressure after treatment, blood pressure compliance of 62.8%, 62.3% and 58.8%. A fixed dose of perindopril and amlodipine combined with safe, tolerable. Conclusion The combination of a fixed dose of perindopril and amlodipine is a safe and effective treatment for essential hypertension and has good clinical compliance.