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目的:探讨西甲硅油乳剂联合枯草杆菌肠球菌二联活菌肠溶胶囊(美常安)在肠易激综合征(IBS)治疗中的临床效果。方法:将2014年1月至2015年10月收治的180例IBS患者随机分为西甲硅油乳剂联合枯草杆菌肠球菌二联活菌治疗组92例和单药枯草杆菌肠球菌二联活菌治疗对照组88例,治疗4周后随访观察两组患者的治疗总有效率、不同胃肠症状的治疗有效率,以及不同型IBS患者的胃肠症状评分。结果:IBS治疗组的治疗总有效率为88.0%,明显高于对照组70.5%(P<0.05)。治疗4周后腹胀和排便次数改善的有效率分别为94.6%和78.3%明显高于对照组的77.3%和60.2%(P<0.05),但两组在腹痛和排便性状改善方面比较无明显差异(P>0.05)。对两组不同胃肠症状评分结果:显示同组同型IBS治疗4周后胃肠症状评分均明显低于治疗前(P<0.05)治疗有效。但两组同型IBS患者的治疗后胃肠症状评分比较时,仅在便秘型IBS患者差异明显(P<0.05)。结论:西甲硅油乳剂联合枯草杆菌二联活菌肠溶胶囊对肠易激综合征(IBS)患者治疗有效,对缓解腹胀和改善排便次数上治疗效果尤为明显,对IBS便秘型患者的胃肠症状恢复疗效最佳。
Objective: To investigate the clinical effect of Simethicone Emulsion combined with Bacillus subtilis Enterococcus (COM) in the treatment of irritable bowel syndrome (IBS). Methods: One hundred and eighty patients with IBS who were admitted from January 2014 to October 2015 were randomly divided into two groups: 92 cases of simethicone emulsion combined with B. subtilis enterococci viable and 92 cases of B. subtilis and B. subtilis alone (N = 88). After 4 weeks of treatment, the total effective rate of treatment, the treatment efficiency of different gastrointestinal symptoms, and the gastrointestinal symptom scores of different IBS patients were observed. Results: The total effective rate of treatment in IBS group was 88.0%, which was significantly higher than that in control group (70.5%, P <0.05). After 4 weeks of treatment, the effective rates of improving the frequency of bloating and defecation were 94.6% and 78.3%, respectively, significantly higher than those of the control group (77.3% and 60.2%, P <0.05). However, there was no significant difference between the two groups in improving abdominal pain and defecation (P> 0.05). The results of two groups of different gastrointestinal symptoms score: The same group of IBS 4 weeks after treatment of gastrointestinal symptoms scores were significantly lower than before treatment (P <0.05) effective. However, when compared with post-treatment gastrointestinal symptom score, the difference was significant only in patients with constipation type IBS (P <0.05). Conclusion: Simethicone Emulsion combined with Bacillus Subtilis and Bacillus subtilis enteric-coated enteric-coated capsules are effective in treating patients with irritable bowel syndrome (IBS), especially in relieving bloating and improving defecation frequency. The gastrointestinal symptoms of patients with IBS constipation Restore the best effect.