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目的分析呼吸道铜绿假单胞菌体外药敏试验结果。方法分离481株铜绿假单胞菌,以琼脂稀释法进行体外药敏试验,根据最小抑菌浓度(MIC)判断铜绿假单胞菌及亚胺培南不敏感菌株的敏感性、耐药性及中介率。结果呼吸道铜绿假单胞菌对亚胺培南耐药性最低(12.06%),对美罗培南的耐药性次之(13.93%),对复方新诺明耐药性最高(99.79%)。96株亚胺培南不敏感菌株对阿米卡星耐药性最低(16.67%),对复方新诺明耐药性最高(98.96%)。结论针对我院铜绿假单胞菌耐药性现状,建议以亚胺培南、环丙沙星等抗菌药物进行经验性治疗,在此基础上联用阿米卡星有望取得较好的疗效。
Objective To analyze the drug susceptibility test results of respiratory Pseudomonas aeruginosa in vitro. Methods 481 Pseudomonas aeruginosa strains were isolated and tested by agar dilution method in vitro susceptibility test. The sensitivity, drug resistance of Pseudomonas aeruginosa and imipenem-insensitive strains were determined according to the minimum inhibitory concentration (MIC) Intermediary rate. Results Respiratory aeruginosa had the lowest resistance to imipenem (12.06%), followed by meropenem (13.93%) and the highest (99.79%) to cotrimoxazole. 96 strains of imipenem-insensitive strains showed the lowest resistance (16.67%) to amikacin and the highest (98.96%) to cotrimoxazole. Conclusions In view of the current status of drug resistance of Pseudomonas aeruginosa in our hospital, it is suggested that empirical treatment with antibiotics such as imipenem and ciprofloxacin should be conducted on the basis of which the combination of amikacin is expected to achieve better therapeutic effect.