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对口服避孕药的诱变效果的研究至今还很少见,Badr等的早期工作证明,雌性小白鼠大剂量服用该药后,显性致死突变率很高,但在口服避孕药引起服用妇女的染色体畸变率方面,后来的一些研究结果互相矛盾,因此作者对口服避孕药的服用者的姊妹染色单体互换(SCE)频率进行了研究,因为SCE是目前公认的测定药物诱变活力比较敏感的指标。作者选择了45名妇女作为试验对象,其中15人是正常健康妇女,15人是怀孕7～9个月的妇女,15名妇女为口服避孕药服用者。每人每天口服含d-甲基炔诺酮 15μg、乙烯基雌二醇30～50μg的避孕药,连续服药6～24个月(平均16个月),这些妇女的年
Studies on the mutagenic effects of oral contraceptives are still rare until now. Early work by Badr et al. Showed that after taking this drug in high doses in female mice, the rate of dominant lethal mutation is high, but women taking oral contraceptives In terms of chromosomal aberrations, some later conflicting studies led to the study of sister chimer exchange (SCE) frequency among users of oral contraceptives because SCE is now more generally accepted as a measure of the potency of drug-induced mutagenesis index of. The authors selected 45 women as subjects, 15 of whom were normal healthy women, 15 were women who were 7 to 9 months pregnant and 15 were women who took oral contraceptives. Each person daily oral contraceptives containing 15μg of d-norgestrel and 30 ~ 50μg of vinyl estradiol for 6-24 months (average 16 months), the years of these women