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目的:探讨雾化吸入布地奈德联合高渗盐水治疗毛细管支气管炎临床效果。方法:选取2012年10到2014年10月100例毛细管支气管炎患者为研究对象,分成2组,有明确细菌感染者,给予敏感抗生素头孢呋辛钠80 mg/kg,每日2次,或美洛西林钠80-100 mg/kg,每日2次,此外给予对症治疗,如止咳化痰(羚贝止咳糖浆)。对照组50例,予高渗盐水治疗,吸入0.9%氯化钠注射液2 m L和吸入用布地奈德混悬液(普米克令舒)1 mg/次混合液,观察50例,吸入3%氯化钠注射液2 m L配合吸入用布地奈德混悬液(普米克令舒)1 mg/次,观察治疗后相关指标变化情况。结果:疗效观察,对照组显效率62%,总有效率82%,观察组显效率78%,总有效率92%,两组比较差异有统计学意义(P<0.05);肺功能上,两组治疗前后在FEV1、FVC、PEF、FVC/FEV1对比差异明显(P均<0.05),组间对比差异明显(P<0.05);两组治疗后在咳嗽、哮鸣音、胸闷气短、住院时间比较差异有统计学意义(P均<0.05)。结论:雾化吸入布地奈德联合高渗盐水治疗毛细管支气管炎临床效果显著。
Objective: To investigate the clinical effect of inhaled budesonide combined with hypertonic saline on capillary bronchitis. Methods: From October 2012 to October 2014, 100 patients with capillary bronchitis were enrolled in this study. Patients were divided into two groups and patients with definite bacterial infection were given the antibiotic cefuroxime sodium 80 mg / kg twice daily or the United States Losillin sodium 80-100 mg / kg, 2 times a day, in addition to symptomatic treatment, such as cough and phlegm (Antelope cough syrup). Control group of 50 patients were treated with hypertonic saline, inhaled 0.9% sodium chloride injection 2 ml and inhalation of budesonide suspension (Pulmicort resp. 1 mg / times mixture, observed 50 cases, inhalation 3 % Sodium chloride injection 2 m L with inhalation of budesonide suspension (Pulmicort resp.) 1 mg / time to observe changes in relevant indicators after treatment. Results: The curative effect was observed in the control group, the effective rate was 62%, the total effective rate was 82%, the observation group was 78% effective rate, the total effective rate was 92%, the difference between the two groups was statistically significant (P <0.05) There were significant differences in FEV1, FVC, PEF and FVC / FEV1 between the two groups before and after treatment (P <0.05), and there was significant difference between the two groups (P <0.05). After treatment, the cough, wheeze, chest tightness, The difference was statistically significant (P <0.05). Conclusion: The therapeutic effect of inhaled budesonide and hypertonic saline on capillary bronchitis is remarkable.