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关于急性粒细胞白血病(AML)化疗患者发热性白细胞减少症期间血浆细胞因子水平临床意义的前瞻性研究文献中很少报道,为此,作者对一组强化化疗的AML患者血浆炎性及抗炎性细胞因子水平进行了前瞻性研究。 20例AML患者,年龄17～69岁,男性9例,女性11例,共行23个疗程化疗,其中20个疗程采用柔红霉素、阿糖胞苷、足叶乙甙方案,另3个疗程采用阿糖胞苷或大剂量阿糖胞苷加米妥蒽醌方案。发热病人给予头孢他啶、妥布霉素及替考拉宁治疗,14例发热持续超过48小时病人加用两性霉素B。18例患者至少有一次以上发热.11例有严重感染(肺炎4例,败血症3例、重症小肠结肠炎3例、肝炎1例)。所有病人每周
The clinical significance of plasma cytokine levels during febrile leukopenia in patients with acute myelogenous leukemia (AML) chemotherapy has rarely been reported in the literature. To this end, the authors investigated the plasma inflammatory and anti-inflammatory effects of a group of intensive chemotherapy patients with AML. The level of sex cytokines was prospectively studied. 20 patients with AML, aged 17 to 69 years, 9 males and 11 females, were treated with 23 courses of chemotherapy, 20 of which included daunorubicin, cytarabine, and acetylcholine, and the other 3 The course of treatment used cytarabine or high-dose cytarabine plus Metoprolol regimen. Fever patients were treated with ceftazidime, tobramycin, and teicoplanin. Fourteen patients with fever who continued for more than 48 hours were treated with amphotericin B. Eighteen patients had fever at least once or more. Eleven patients had severe infections (4 cases of pneumonia, 3 cases of sepsis, 3 cases of severe enterocolitis, and 1 case of hepatitis). All patients weekly