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观察氟他胺（Ｆｌｕ）抗前列腺肥大的作用方法：以两种动物模型：阉割大鼠每只每日ｓｃ睾酮０．５ｍｇ引起前列腺肥大和小鼠前列腺中植入同系 １６ ｄ龄胎鼠的尿生殖窦组织， ｉｇ Ｆｌｕ １０， ２５，和５０ ｍｇ·ｋｇ－１ ３０ ｄ或 ｓｃ雌二醇（Ｅｓｔ），两模型分别持续３０ ｄ和 １４ｄ．结果：１） Ｆｌｕ能显著抑制大鼠各叶前列腺体积和重量，使其降至对照组的１０％至５０％，并呈良好的剂量效应关系．腺体上皮萎缩，腺腔直径缩小，其效应比Ｅｓｔ强．２）Ｆｌｕ治疗组前列腺体积和重量均减小，但只有体积项呈剂量效应关系此模型中，Ｅｓｔ的作用较Ｆｌｕ强．结论： Ｆｌｕ具有抑制前列腺肥大的作用。
To observe the effect of flutamide on anti-prostatic hypertrophy. Methods: Two animal models were established: castrated rats received 0.5 mg of testosterone per day, respectively, causing prostatic hypertrophy and urinary sterility in mice implanted with 16-d-old fetus Reproductive sinus tissue, ig Flu 10, 25, and 50 mg · kg-1 for 30 days or Est (est), respectively. The two models last for 30 d and 14 d, respectively. Results: 1) Flu could significantly inhibit the volume and weight of the prostate of each leaf in rats, reducing it to 10% to 50% of the control group and showing a good dose-response relationship. Glandular epithelial atrophy, gland cavity diameter reduced, its effect stronger than Est. 2) The volume and weight of prostate in the Flu treatment group decreased, but only the volume effect was dose-dependent. In this model, the effect of Est was stronger than Flu. Conclusion: Flu has an inhibitory effect on prostatic hypertrophy.