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目的研究血管紧张素Ⅱ1型受体基因多态性是否与冠心病的发病相关。方法通过冠状动脉造影检查,共收集了455例冠心病患者和465例对照。采用等位基因特异性PCR对血管紧张素Ⅱ1型受体SNP位点rs5186(A1166C)进行基因分型,最后进行统计分析。结果共检测了455例冠心病患者和465例对照。基因分型结果显示,在冠心病病人和对照之间,SNP rs5186基因型存在差异,AA基因型降低冠心病的发病风(OR=0.57,P<0.001)。结论血管紧张素Ⅱ1型受体基因多态性与冠心病的发病相关,SNP 1166AA是冠心病发病的保护因素。
Objective To investigate whether angiotensin Ⅱ type 1 receptor gene polymorphism is associated with the pathogenesis of coronary heart disease. Methods By coronary angiography, a total of 455 patients with coronary heart disease and 465 controls were collected. Allele-specific PCR was used to genotype the rs5186 (A1166C) SNP site of angiotensin Ⅱ type 1 receptor, and finally statistical analysis was performed. Results A total of 455 patients with coronary heart disease and 465 controls were examined. Genotyping results showed that genotypes of SNP rs5186 were different between CHD patients and controls. AA genotypes decreased the incidence of CHD (OR = 0.57, P <0.001). Conclusion The polymorphism of angiotensin Ⅱ type 1 receptor gene is associated with the pathogenesis of coronary heart disease. SNP 1166AA is the protective factor of coronary heart disease.