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强直性脊柱炎(AS)是一种以骶髂关节炎为标记性特点,以中轴关节慢性炎症为主要表现,也可累及内脏及其他组织的慢性进展性风湿性疾病。多发生于10～40岁人群,发病高峰年龄为20～30岁,40岁以后发病者少见。对AS的认识可以说是自1691年O’Connor首次报道开始,至今已有300余年。但先前一直认为本病是类风湿关节炎(RA)的特殊类型。直到70年代,发现AS与HLA-B27强相关以后,才认识到本病与RA不是一个病。由于本病病因未明,治疗问题迄今未能解决,典型病例脊柱发生强直后,病情不能逆转,故此,早期诊断成为争取良好预后的关键。作者就有关AS的诊断治疗要点概述如下。
Ankylosing spondylitis (AS) is a marked feature of sacroiliac arthritis, chronic axial inflammation of the central axis as the main performance, but also can affect the internal organs and other chronic progressive rheumatic diseases. Occurred in 10 to 40-year-old crowd, the peak incidence age of 20 to 30 years old, 40 years of age after the onset of rare. Recognition of AS can be said that since the first report of O’Connor in 1691, it has been more than 300 years. However, this disease has been previously considered a particular type of rheumatoid arthritis (RA). It was not until the 1970s that AS was found to be strongly associated with HLA-B27 before it was recognized that this disease was not a disease with RA. As the etiology of this disease is unknown, the treatment problem has so far failed to solve, typical cases of spinal ankylosis, the condition can not be reversed, therefore, early diagnosis has become the key to good prognosis. The authors summarize the main points of diagnosis and treatment of AS as follows.