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作者研究了葡萄籽中原花青素类(低聚儿茶素部位)体外对人多形核白细胞氧化性突发呼吸和溶酶体酶释放是否有抑制作用,以确定其在抗炎介入疗法中是否有益。考察的3种溶酶体酶为骨髓过氧化物酶(MPO)、β-葡糖苷酸酶(B)及弹性蛋白酶(E)。结果表明,原花青素浓度相关地抑制过氧化物的生成,IC_(50)为7.2μmol/L,浓度为0.5～15μmol/L 时,抑制率为10.3％～87％,对照药儿茶素和槲皮素的 IC_(50)分别为33.3和42.4μmol/L。原花青素抑制氮蓝四
The authors investigated whether proanthocyanidins (oligo-catechin sites) in grape seed have an inhibitory effect on oxidative burst respiratory and lysosomal enzyme release from human polymorphonuclear leukocytes in vitro to determine whether they are beneficial in anti-inflammatory interventional therapies. . The three lysosomal enzymes examined were myeloperoxidase (MPO), β-glucuronidase (B) and elastase (E). The results showed that the concentration of procyanidins inhibited the production of peroxides, IC50 was 7.2 μmol/L, and the concentration was 0.5-15 μmol/L. The inhibition rate was 10.3% to 87%. The control drugs catechin and suede The IC 50 of the element were 33.3 and 42.4 μmol/L, respectively. Proanthocyanidin inhibits nitrogen blue four