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目的探讨抗抑郁治疗对老年高血压患者降压疗效的影响。方法对138例老年高血压合并抑郁的患者随机分为A、B组,并设103例老年高血压患者对照组,三组均给予氢氯噻嗪12．5mg/d和硝苯地平控释片30 mg/d口服,A组在此基础上加服氟西汀20 mg/d口服,共12周；B组给予阿米三嗪1片和谷维素20 mg,3次/d,共12周。结果A组与治疗前及B组相比,其坐位血压、24 h动态血压监测昼夜收缩压和舒张压均明显下降,差异有显著的统计学意义(P＜0．01)。结论抗抑郁治疗有利于老年高血压合并抑郁患者的血压控制。
Objective To investigate the effect of antidepressant on the antihypertensive efficacy of elderly hypertensive patients. Methods A total of 138 elderly patients with hypertension and depression were randomly divided into A and B groups and 103 elderly hypertensive patients. The three groups were given hydrochlorothiazide 12.5 mg / d and nifedipine 30 mg / d oral, group A on the basis of plus fluoxetine 20 mg / d orally for 12 weeks; group B was given amiltrazine and oryzanol 20 mg, 3 times / d for 12 weeks. Results Compared with those before treatment and in group B, the blood pressure in sitting position and the systolic and diastolic pressure in ambulatory blood pressure monitoring in 24 hours were significantly decreased in group A, with significant difference (P <0.01). Conclusions Antidepressant therapy is beneficial to control blood pressure in elderly patients with hypertension and depression.