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本文报道香菇菌多糖对实验性肝损伤的保护作用。此药能明显降低CCl_4、硫代乙酰胺和强的松龙等化学物质损伤肝脏引起的SGPT升高;能拮抗CCl_4肝损伤小鼠的肝糖元含量降低;并能使正常小鼠肝匀浆细胞色素P-450含量显著增加。小鼠腹腔注射LD_(50)±95％可信限为601.17±43.56mg/kg。
This article reports the protective effect of mushroom polysaccharides on experimental liver injury. The drug can significantly reduce the CCl 4, thioacetamide and prednisolone and other chemicals damage to the liver caused by increased SGPT; CCl 4 liver can antagonize the liver glycogen content is reduced; and can make normal mouse liver homogenate Cytochrome P-450 content increased significantly. The intraperitoneal LD_ (50) ± 95% confidence interval for mice was 601.17 ± 43.56 mg / kg.