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为了解卵巢癌变过程中Ｐ５３的变化及其意义，应用免疫组化技术，研究了５例正常卵巢，２１例卵巢腺瘤，１０例交界性肿瘤，４０例上皮性卵巢癌及１９例大网膜转移灶组织中Ｐ５３蛋白的变化。结果发现：Ｐ５３表达仅见于卵巢癌组织中，浆液性癌的阳性表达率（１５／２２）显著高于粘液性癌（３／１３）和子宫内膜样癌（１／５）（Ｐ＜００５）；Ｐ５３在卵巢癌原发灶和其相应大网膜转移灶中的表达基本一致；Ｐ５３标记指数与卵巢癌组织学分级有关，Ⅱ、Ⅲ级癌的Ｐ５３标记指数显著高于Ⅰ级癌（Ｐ＜００５）。结果提示：Ｐ５３蛋白聚集变化主要发生在卵巢癌变的晚期，Ｐ５３表达有助于良恶性病变的鉴别；卵巢癌为单中心起源；Ｐ５３标记指数与卵巢癌的组织学分级呈正相关
In order to understand the changes and significance of P53 during ovarian carcinogenesis, 5 cases of normal ovarian, 21 cases of ovarian adenoma, 10 cases of borderline tumor, 40 cases of epithelial ovarian cancer and 19 cases of omentum were studied by immunohistochemical technique. Changes of P53 protein in metastatic tissue. The results showed that P53 expression was only found in ovarian cancer tissues, and the positive rate of serous carcinoma (15/22) was significantly higher than that of mucinous carcinoma (3/13) and endometrioid carcinoma (1/5) (P<0). 05); P53 expression in primary ovarian cancer and its corresponding omental metastases is basically the same; P53 marker index and histological grade of ovarian cancer, II, III grade P53 marker index was significantly higher than the I level Cancer (P<005). The results suggest that the accumulation of P53 protein mainly occurs in the advanced stage of ovarian cancer. The expression of P53 contributes to the differentiation of benign and malignant lesions. The ovarian cancer is of single center origin; P53 marker index is positively correlated with the histological grade of ovarian cancer.