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血管内皮素是Yanagisa Wa等于1988年首先从猪主动脉内皮细胞中分离纯化出的血管活性多肽,由21个氨基酸残基组成,以后在人和大鼠血管内皮细胞中也证实有内皮素(Endathelin,ET)存在。它具有强大的收缩血管和促进血管平滑肌细胞增殖的反应。在生理状态,机体的自身调节网络,可维持ET的基础和/或适应于生理水平的合成与释放,参与内环境稳定的调节。在病理状态下,内源性生物活性物质由环境理化因素或内毒素、缺血、缺氧等影响ET的表达和释放稳态的恒定,可导致ET异常表达和释放,参与疾病的发展过程。绝大部分均是动物试验结果,临床观察材料很少。本文观察62例急性脑梗塞患者在急性期治
Endothelin is a kind of vasoactive peptide isolated and purified from porcine aortic endothelial cells by Yanagisa Wa, which is equal to 1988. It consists of 21 amino acid residues, and later endothelin is also confirmed in human and rat vascular endothelial cells , ET) exists. It has potent vasoconstriction and promotes the proliferation of vascular smooth muscle cells. In the physiological state, the body’s own regulatory network, can maintain the basis of ET and / or adapt to the physiological level of synthesis and release, to participate in the regulation of the internal environment. Under the pathological conditions, endogenous bioactive substances are regulated and released by the environmental physicochemical factors or endotoxin, ischemia, hypoxia and other steady-state constant, can lead to ET abnormal expression and release, involved in the development of the disease. Most are animal test results, the clinical observation of very little material. This article observed 62 cases of acute cerebral infarction in patients with acute phase