论文部分内容阅读
目的:分析原发性中枢神经系统淋巴瘤的临床特点,提高临床诊断率。方法:结合文献对4例原发性中枢神经系统淋巴瘤患者的临床特点、病理学检查、影像学表现、治疗及预后进行回顾性分析。结果:4例患者以颅内压升高和神经功能缺损为主要临床表现,病理检查结果均为非何杰金淋巴瘤(B细胞型)。4例均行手术切除,术后给予联合放化疗、单纯化疗或放疗,至随访终点,2例患者死亡,平均存活时间为20个月。结论:原发性中枢神经系统淋巴瘤的诊断需结合临床特点和影像学表现来综合判定,确诊必须依赖病理学检查;原发性中枢神经系统淋巴瘤预后不佳,手术治疗是PCNSL的主要治疗方法,术后应积极放化疗。
Objective: To analyze the clinical features of primary central nervous system lymphoma and improve the clinical diagnosis rate. Methods: The clinical features, pathological findings, imaging findings, treatment and prognosis of 4 patients with primary central nervous system lymphoma were analyzed retrospectively. Results: In 4 patients, the intracranial pressure and neurological deficits were the main clinical manifestations. The pathological findings were all non-Hodgkin’s lymphoma (B cell type). Four patients underwent surgical resection. Patients were given combined chemoradiotherapy and chemotherapy or radiotherapy. At the end of follow-up, two patients died and the mean survival time was 20 months. Conclusion: The diagnosis of primary central nervous system lymphoma should be combined with clinical features and imaging findings to determine the diagnosis must rely on pathological examination; poor prognosis of primary central nervous system lymphoma, surgical treatment of PCNSL is the main treatment Methods, postoperative radiotherapy and chemotherapy should be actively.