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人粒细胞巨噬细胞集落刺激因子(hGM-CSF)在调节机体的重要功能中有重要作用,其基因表达受一系列正、负调控元件及多种转录因子的调控,它的5’侧翼区及3’侧翼区对其表达有重要作用。基因的表达水平受转录及转录后调控,且显示有组织特异性。
Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) plays an important role in the regulation of important functions of the body. Its gene expression is regulated by a series of positive and negative regulatory elements and a variety of transcription factors. Its 5 ’flanking region And 3 ’flanking region play an important role in its expression. The level of gene expression is post-transcriptionally and post-transcriptionally regulated and shows tissue specificity.