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以成年母鸡 ( 1 2月龄 )为实验动物 ,对灭多威原药进行了迟发性神经毒性的研究。设计剂量为 5、1 2 .5和 2 5mg/kg三个剂量组 ,同时设一阴性对照组 (熟豆油 )和一阳性对照组 (磷酸三甲苯酯 :TOCP)。染毒后持续观察 2 1天 ,记录动物中毒症状和临床表现 ;2 1天后未观察到神经毒性反应 ,重复染毒一次 ,继续观察 2 1天。结果表明 :阴性对照组及试验组动物未出现迟发性神经毒性反应 ;阳性对照组动物表现出明显的迟发性神经毒性反应。
Adult hen (12 months old) as experimental animals, the original drug Domvastatin delayed neurotoxicity studies. Three doses of 5, 12.5, and 25 mg / kg were designed and a negative control (cooked soybean oil) and a positive control (tricresyl phosphate: TOCP) were also included. Observed after 21 days of exposure to poisoning symptoms and clinical manifestations of animals; 21 days after the observed no neurotoxic reaction, once repeated exposure to continue to observe 21 days. The results showed that there was no delayed neurotoxic reaction in the negative control group and the experimental group, while the animals in the positive control group showed obvious delayed neurotoxic reaction.