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支气管哮喘是由多种细胞和细胞组分参与的气道慢性炎症性疾病,临床表现为反复发作性喘息、咳嗽、气促和胸闷等症状[1]。内皮素(endothelin,ET)是最强烈的支气管收缩剂,ET不仅存在于血管内皮细胞,而且气管、支气管黏膜、平滑肌、肺血管、肺泡上皮细胞亦有ET存在,其中ET-1
Bronchial asthma is a chronic inflammatory disease of the airways involved in a variety of cellular and cellular components, with recurrent episodes of wheezing, cough, shortness of breath, and chest tightness [1]. Endothelin (ET) is the most intense bronchoconstrictor. ET is not only found in vascular endothelial cells, but also exists in the trachea, bronchial mucosa, smooth muscle, pulmonary artery and alveolar epithelial cells. ET-1