论文部分内容阅读
目的探讨血浆肾素、血管紧张素II、醛固酮水平在高血压病患者治疗前后的临床意义。方法选择原发性高血压病人122例,其中轻型20例,中型78例,重型24例,分别于治疗前后用放射免疫方法测定血浆PRA、AngII、ALD含量。结果高压组血浆PRA、AngII、ALD含量明显高于对照组(P<0.01);轻、中、重型三组血浆PRA、AngII、ALD含量呈逐步升高态势,组间相互比较有显著性和非常显著性意义(P<0.05~0.01);治疗后血浆PRA、AngII、ALD含量有较明显的降低,与治疗前比较有非常显著性意义(P<0.01)。结论降低原发性高血压患者血浆PRA、AngII、ALD含量是治疗高血压病的关键;血浆PRA、AngII、ALD是监测原发性高血压病疗效的可靠而且灵敏的指标。
Objective To investigate the clinical significance of plasma renin, angiotensin II and aldosterone in patients with essential hypertension before and after treatment. Methods 122 patients with essential hypertension were selected, including 20 cases of light type, 78 cases of medium size and 24 cases of heavy type. Plasma PRA, AngII and ALD levels were measured by radioimmunoassay before and after treatment. Results The contents of plasma PRA, AngII and ALD in high pressure group were significantly higher than those in control group (P <0.01). The levels of plasma PRA, AngII and ALD in mild, moderate and severe groups were gradually increased, with significant difference between the two groups (P <0.05 ~ 0.01). After treatment, the levels of plasma PRA, AngII and ALD were significantly lower than those before treatment (P <0.01). Conclusions Reducing plasma PRA, AngII and ALD levels in patients with essential hypertension is the key to the treatment of hypertension. Plasma PRA, AngII and ALD are reliable and sensitive indicators for monitoring the efficacy of essential hypertension.