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James Black等发现的H_2受体拮抗剂预示了治疗消化性溃疡病的一个重要突破。1977年甲氰咪胍被引进临床医疗,治疗的重心一夜间从外科医师倾向内科医师。在曾一度担心甲氰咪胍可能掩盖或甚至引起胃癌后,该药迅速被接受作为消化性溃疡病人的首选药
H 2 receptor antagonists such as those found by James Black are predictive of an important breakthrough in the treatment of peptic ulcer disease. Cimetidine was introduced into clinical medicine in 1977, and the focus of treatment tended to be physicians from surgeons overnight. The drug was quickly accepted as the drug of choice for patients with peptic ulcer after it was once feared that cimetidine may mask or even cause stomach cancer