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药物与受体的相互作用,是药效的物质基础。酶作为受体的一种是许多药物的作用对象。研究药物或化合物与酶的作用是解析酶的结构和阐明酶作用机制的重要手段,并且对了解药物的作用原理和新药设计也有重要意义。生物化学及药学从不同的侧面研究酶的抑制剂或失活剂,企图获得具有特异作用的化合物。作为药物,应选择性地仅与靶部位的酶作用,尽量减少在体内转运过程与机体任何其它成份作用或代谢,或在靶部位与其它酶系产生反应。近年来,酶的特异性不可逆抑制剂又称为催化常
Drug interactions with receptors, is the material basis of efficacy. Enzymes as a receptor is the role of many drugs. Studying the effect of a drug or compound and an enzyme is an important means of resolving the structure of an enzyme and clarifying the mechanism of action of the enzyme and is also of great importance in understanding the principle of action of a drug and designing a new drug. Biochemistry and Pharmacology Research inhibitors or deactivators of enzymes from different aspects in an attempt to obtain compounds with specific effects. As a drug, it should selectively act only on the enzyme at the target site to minimize the effect or metabolism of any other component of the body during transport in the body or to react with other enzymes at the target site. In recent years, enzyme-specific irreversible inhibitors, also known as catalytic