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1.人血清在体内外可促进人牙髓干细胞的成骨分化(英)/Pisciotta A…//PLoS One.-2012,7(11).-e50542人牙髓干细胞(hDPSCs)是以细胞为基础的组织工程研究中很有前途的种子细胞来源,易获取,对病人侵袭性低,细胞可自我更新和多向分化。目前,间充质干细胞体外培养通常添加含胎牛血清(FCS)的培养基。FCS含大量生长因子,可促进细胞在塑料表面的附着、增殖和分化。然而,动物源性的FCS可能传播疾病,甚至导致异体免疫反应。因此,
1. Human Serum Enhances Osteogenic Differentiation of Human Dental Pulp Stem Cells in vitro and in vivo (English) / Pisciotta A ... // PLoS One.-2012,7 (11) .- e50542 Human dental pulp stem cells (hDPSCs) Promising source of seed cells in underlying tissue engineering research, accessible, patient-invasive, cells self-renewing and multi-directional differentiation. At present, mesenchymal stem cells cultured in vitro usually contain medium containing fetal bovine serum (FCS). FCS contains a large number of growth factors, can promote cell adhesion to the plastic surface, proliferation and differentiation. However, animal-derived FCS may spread the disease and even cause allogeneic immune responses. therefore,