论文部分内容阅读
目的研究亚低温对重症脑血管病和重型颅脑创伤患者的临床疗效。方法98例重症脑血管病和重型颅脑创伤患者,随机分为亚低温组(48例)、常规治疗组(50例)。亚低温组于病后24h内行局部亚低温治疗,使脑温控制在32~35℃,维持1~7d,同时监测病人的生命体征、颅内压、血糖、血气、电解质变化。常规治疗组体温维持在36~37℃,其它治疗同亚低温组。两组患者均于病后3个月根据GOS标准判定疗效。结果亚低温组于治疗早期颅内压、血糖等异常指标分别下降(均P<0·05);血浆Mg2+水平升高(P<0·05)。亚低温组病死率、恢复良好率及患者预后均显著优于常规治疗组(P<0·05)。结论亚低温治疗具有肯定的脑保护作用。临床用于治疗重症脑血管病及重型颅脑创伤病人,可降低病死率,改善预后,提高生存质量。
Objective To study the clinical effect of mild hypothermia on patients with severe cerebrovascular disease and severe traumatic brain injury. Methods A total of 98 patients with severe cerebrovascular disease and severe traumatic brain injury were randomly divided into mild hypothermia group (n = 48) and conventional treatment group (n = 50). The mild hypothermia group was treated with local mild hypothermia 24h after the illness, so that the brain temperature was controlled at 32-35 ℃ for 1 ~ 7 days. Meanwhile, vital signs, intracranial pressure, blood glucose, blood gas and electrolytes were monitored. Conventional treatment group was maintained at 36 ~ 37 ℃ body temperature, other treatment with mild hypothermia. Two groups of patients in the disease after 3 months according to GOS criteria to determine the efficacy. Results The levels of abnormal intracranial pressure and blood glucose in the mild hypothermia group decreased in the early stage of treatment (all P <0.05), while the level of plasma Mg2 + increased (P <0.05). Mild hypothermia group, good recovery and prognosis of patients were significantly better than the conventional treatment group (P <0.05). Conclusion Mild hypothermia has a positive brain protective effect. Clinical treatment of patients with severe cerebrovascular disease and severe traumatic brain injury, can reduce mortality, improve prognosis and improve the quality of life.