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采用预聚-扩链-中和-分散法合成了端羟基聚二甲基硅氧烷(DHPDMS)改性聚氨酯(PU)水溶液,再将PU水溶液和淀粉(ST)溶液按照不同的质量比进行复合,采用凝聚相分离法制备出PDMS-PU/ST复合微球;考察了PEG分子量、n(-OH)/n(-NCO)、DHPDMS的质量分数,淀粉质量分数对PDMS-PU/ST复合微球的球形、力学强度和降解率的影响。并通过扫描电子显微镜(SEM)和傅立叶变换红外光谱(FT-IR)对微球的表面形态和化学结构进行表征,SEM照片显示复合微球表面光滑且内部有很多致密的管状孔隙,适合用作药物释放载体材料;FT-IR表明硅氧键引入到PU中,且PU和ST之间通过氢键复合。
The hydroxyl-terminated polydimethylsiloxane (DHPDMS) modified polyurethane (PU) aqueous solution was synthesized by prepolymerization-chain extension-neutralization-dispersion method. The PU aqueous solution and starch (ST) solution were further mixed at different mass ratios PDMS-PU / ST composite microspheres were prepared by coacervation phase separation method. The effects of PEG molecular weight, n (-OH) / n (-NCO), DHPDMS mass fraction and starch mass fraction The microspheres’ spherical shape, mechanical strength and degradation rate. The surface morphology and chemical structure of the microspheres were characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FT-IR). The SEM images showed that the microspheres had a smooth surface and many dense tubular pores inside and were suitable for The drug release carrier material; FT-IR indicates that the siloxane bond is introduced into the PU and the hydrogen bonds between the PU and the ST are complexed.