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作者利用人体卵巢癌的转移瘤建立了裸鼠移植瘤模型,现已传至第8代。移植成功率为100％。发现传代后仍具有原人卵巢癌转移的生物学行为。经光学显微镜检查传至8代的瘤组织结构与原发瘤相同。电镜检查证明具有卵巢癌特有的特征,癌细胞间组成徽腔——原始腺腔,表面可见微绒毛,核中常染色质占绝对优势,胞浆中有丰富的多聚核糖体。该模型为研究人卵巢癌生物学特性、实验治疗等提供了有用工具。
The use of human ovarian cancer metastases established a nude mouse xenograft model has been passed to the eighth generation. Transplant success rate was 100%. Found that after passage still has the biological behavior of human ovarian cancer metastasis. The tumor tissue transmitted to the 8th generation by optical microscopy was the same as the primary tumor. Electron microscopy proved ovarian cancer has the unique characteristics of cancer cells composed of Hui cavity - the original gland cavity, the surface of microvilli, the nucleus of the dominant chromatin, cytoplasm rich in polysome ribosome. The model provides a useful tool for studying the biological characteristics of human ovarian cancer and experimental treatment.