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卡氏肺孢子虫是一种细胞外寄生虫,是免疫抑制宿主特别是艾滋病患者主要的致死病原。肺孢子虫需附着于肺泡上皮细胞上生长和繁殖,易与Ⅰ型肺泡上皮细胞结合。以往的研究证实细胞外基质蛋白的纤连蛋白Fn在肺孢子虫与宿主细胞附着过程中的介质作用。Fn特异地与肺孢子虫表面的糖蛋白gp120连接,gp120是一种110—120kDa高
Pneumocystis carinii is an extracellular parasite that is the major lethal cause of immunosuppressed hosts, especially AIDS patients. Pneumocystis to be attached to the alveolar epithelial cells on the growth and reproduction, easy to type Ⅰ alveolar epithelial cells. Previous studies have demonstrated the mediator effect of fibronectin Fn, an extracellular matrix protein, on the attachment of Pneumocystis to host cells. Fn is specifically linked to the glycoprotein gp120 on the surface of Pneumocystis, a 110-120 kDa high