Polydopamine and ammonium bicarbonate coated and doxorubicin loaded hollow cerium oxide nanoparticle

• 作 者: Keqiang Xu Yan Cheng Jiao Yan Yanlin Feng Runxiao Zheng Xiaqing Wu Yanjing Wang Panpan Song Haiyuan Zhang
• 机 构: Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Science
• 出 处: 纳米研究（英文版）
• 发表日期: 2019年12期
• 关键词: photothermal therapy chemotherapy chemodynamic therapy polydopamine cerium oxide

The development of effective nanoplatforms is extremely necessary for cancer therapy.Herein,we prepared polydopamine (PDA) and ammonium bicarbonate (NH4HCO3) coated and doxorubicin (Dox) loaded hollow cerium oxide (CeC2) NPs (PDAC NPs),which showed excellent synergistic effect for photothermal therapy,chemotherapy and chemodynamic therapy.Under near infrared laser irradiation,PDA shell could absorb the incident light and convert it into heat,which could not only kill tumor cells with hyperthermia,but also trigger the decomposition of NH4HCO3 into gaseous carbon dioxide and ammonia,leading to the destroy of PDA shell.The leakage of PDA further accelerated Dox release and exposed CeO2 surface,in which Dox could enter into cell nucleus to induce chemotherapy,and CeO2 could catalyze cellular hydrogen.peroxide into hydroxyl radical to present chemodynamic therapy.In fact,PDAC NPs showed an excellent therapeutic efficacy both in vitro and in vivo.This design provides a new strategy for synergistic tumor therapy.